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However, "the selenium trial that was done years ago in people to prevent recurrence of skin cancer actually increased the recurrence of skin cancer," said Alan Kristal, DrPH, a faculty member in the Public Health Sciences Division at the Fred Hutchinson Cancer Research Center in Seattle. Further analysis suggested a prostate cancer risk benefit, said Dr. Sesso, which helped propel the launch of the SELECT trial, the largest prostate cancer prevention study to date that tested the effects of selenium and vitamin E.

Kristal, one of the study's authors. And the most recent analysis even showed increased prostate cancer risk in some men. Kristal agrees. Vitamin E is a fat-soluble antioxidant found in nuts, seeds, and vegetable oils that's also been studied extensively for disease prevention. Substantial research had "suggested that vitamin E would reduce not just cancer risk, but also cardiovascular disease risk," said Dr. However, as Dr. Kristal explained, vitamin E failed to show benefits in people: Most of the trials "found that there doesn't appear to be any obvious benefits to taking individual vitamin E supplements.


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Still, Sesso advises that "there's no reason to take it, either. It's not because of potential risk, but just because of lack of benefit, also.


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    • The extract from the bark of yohimbe, an evergreen tree found in western Africa, is sold over-the-counter, but its active ingredient, yohimbine , is available only by prescription. Yohimbe bark supplements claim to help erectile dysfunction ED , even though "very few studies show that it's very useful," said Keith D.

    According to Dr. Bloom, supplements like yohimbe aim to mimic, to some degree, what Viagra, Cialis, and Levitra do, which is to increase blood flow, but "they just don't do it nearly as well as the prescribed medications do, they don't do it as safely, and they're unregulated," he said. Another issue is that yohimbe doesn't mix well with some commonly prescribed drugs. Users report better sleep and huge increases in sexual function, with no side effects, according to USP Labs. Goliath Labs's Ejaculoid is a top-selling sexual health product, according to VitaminShoppe.

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    The powerful ingredients target both nitric oxide production and optimal testosterone levels. Maca root, tribulus terrestris, GABA and longjack work on hormonal stimulus, while horny goat weed, yohimbe and cnidium monnieri help to increase blood flow to the extremities. Users report huge increases in libido, as well as youthful feelings of vitality and energy.

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    Steel Libido may boost sexual performance and desire by giving blood vessel support to increase blood flow as well as targeted nutraceuticals and traditional botanicals for optimizing hormone levels. Arginine, horny goat weed and NADH, a form of niacin, increase blood flow to the extremities by optimizing nitric oxide production.

    DHEA, horny goat weed, tribulus, maca and CDP choline maximize testosterone and growth hormone levels to increase libido naturally. Journal of Pharmacology and Pharmacotherapeutics. March Do, J.


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