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Based on the overall effects these drugs have, they have been banned since from men's competitions and for women's. On March 7, , former world number one tennis player Maria Sharapova announced that she had failed a drug test in Australia due to the detection of meldonium. She said that she had been taking the drug for ten years for various health issues, and had not noticed that it had been banned.

Bobrova said she was shocked about the test result, because she had been made aware of meldonium's addition to the banned list, and had been careful to avoid products containing banned substances. As a result, the match—scheduled to take place in Russia—was postponed indefinitely by the WBC. Other athletes who are provisionally banned for using meldonium include Ethiopian-Swedish middle-distance runner Abeba Aregawi , [41] Ethiopian long-distance runner Endeshaw Negesse , [42] Russian cyclist Eduard Vorganov , [43] and Ukrainian biathletes Olga Abramova [44] and Artem Tyshchenko.

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The Ice Hockey Federation of Russia replaced the Russia men's national under ice hockey team with an under team for the IIHF World U18 Championships after players on the original roster tested positive for meldonium. More than failed tests by athletes were identified in a relatively brief period after the ban on meldonium was imposed on January 1, , almost all of which were from Eastern European countries. In addition it was reported that five Georgian wrestlers [72] and a German wrestler had tested positive for the drug although no further names were released.

A December study in the journal Drug Testing and Analysis argued that meldonium "demonstrates an increase in endurance performance of athletes, improved rehabilitation after exercise, protection against stress, and enhanced activations of central nervous system CNS functions". It is also believed that meldonium is opposing to steroids in the sense that instead of making the athlete emotionally unstable and readily irritable, it keeps them in an elevated state of mind and keeps their emotions in a happier state. This improves the messaging system throughout the body and, therefore, can decrease improve reaction time for an athlete.

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It said the drug worked mainly by reducing damage to cells that can be caused by certain byproducts of carnitine. According to him, meldonium does not enhance athletic performance in any way, and was rather used by athletes to prevent damage to the heart and muscles caused by lack of oxygen during high-intensity exercise. He contended that not allowing athletes to take care of their health was a violation of their human rights, and that the decision aimed to remove Eastern European athletes from competitions and his drug from the pharmaceutical market.

She also speculated that Russian athletes may not have received adequate warnings that the drug was banned — due to the suspension of the Russian Anti-Doping Agency in late Forbes reported that anesthesiology professor Michael Joyner , at the Mayo Clinic in Rochester, Minnesota , who studies how humans respond to physical and mental stress during exercise and other activities, told them that "Evidence is lacking for many compounds believed to enhance athletic performance.

Its use has a sort of urban legend element and there is not much out there that is clearly that effective. I would be shocked if this stuff [meldonium] had an effect greater than caffeine or creatine a natural substance that, when taken as a supplement, is thought to enhance muscle mass. Meldonium is manufactured by Grindeks , a Latvian pharmaceutical company, with offices in thirteen Eastern European countries [87] as a treatment for heart conditions. From Wikipedia, the free encyclopedia. Not to be confused with medronate or minodronate. For the similarly named reed organ occasionally referred to as a "melodeum", see Melodeon organ.

This scientific article needs additional citations to secondary or tertiary sources such as review articles, monographs, or textbooks. Please add such references to provide context and establish the relevance of any primary research articles cited. Unsourced or poorly sourced material may be challenged and removed. March Learn how and when to remove this template message.

IUPAC name. Interactive image. Archived from the original on 12 March Retrieved 9 March World Anti-Doping Agency. New York Times. Associated Press. Retrieved 8 March CNS Drug Reviews. Biochemical mechanisms and biomarkers of cardiometabolic activity". Pharmacological Research. Mayo Clinic 25 July Retrieved on Behavioral Pharmacology. Reflecting or Inflicting Insulin Resistance? Journal of Sport and Health Science. British Journal of Pharmacology. Klin Med Mosk. CS1 maint: Multiple names: Journal of Cardiovascular Pharmacology and Therapeutics.

Trends in Cardiovascular Medicine. Journal of Neuroscience Research. Chemistry and Biology. Biochemical and Biophysical Research Communications. Chemical Society Reviews. Subscription required help. Biochemical Pharmacology. Vitamins Hormones.

Demonstration of gamma-butyrobetaine hydroxylase activity". Retrieved on 28 May USA Today. Retrieved 7 March January Retrieved 11 March Antidoping Switzerland. The New York Times. International Tennis Federation. Retrieved 15 March The Big Story. Dagens Nyheter in Swedish. Meldonium, the drug in Russia's Olympic doping case".

The Associated Press. Retrieved 19 February Her lawyer responds". Retrieved