Is ginseng a male enhancement

Ginseng has also been reputed as an aphrodisiac, and is used to treat sexual dysfunction as well as to enhance sexual behavior in traditional Chinese medical .
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Thus, there is a need to further understand the causes and to establish measures to prevent it. The initial evidence that ginseng may have positive effects on spermatogenesis was first published in Here it was demonstrated that the stimulatory effect of ginseng extracts on DNA and protein syntheses in rat testes. Ginseng-treated rats have demonstrated an increased rate of spermatogenesis via glial cell-derived neurotrophic factor GDNF expression elevation in Sertoli cells, 30 and activation of testicular cAMP-responsive element modulator CREM.

Ginseng is also found to help preserve the ejaculated sperms. It has been shown that the sperm count of ejaculated sperms that were incubated with ginseng extract was significantly higher than those treated with vehicle.

It is known that conventional cancer treatments often lead to various degrees of reproduction impairment, and that these effects could be either temporary or permanent. Cyclophosphamide CP is an alkylating agent that shows cytostatic effects by forming covalent DNA adducts. Since CP targets rapidly dividing cells, it is extensively used to suppress tumor malignancy, and as an immunosuppressant for organ transplantation patients.

However, this drug often leads to gonadal toxicity, and infertility as a consequence discourages many patients from choosing CP treatment. Radiation therapy is sometimes given to patients as part of the cancer therapy. However, the unselective action of radiation therapy can also damage normal cells, leading to side effects. Amifostine WR is one of the radioprotectants that is registered for human use, but its usage leads to many negative side effects, such as hypertension, nausea, and vomiting. Zearalenone ZEA is an estrogenic mycotoxin that commonly contaminates the environment as its presence in the crops, which causes reproductive disorders in farm animals.

Males with non-insulin-dependent diabetes mellitus type 2 diabetes often suffer from sexual dysfunction. In a double-blinded, placebo-controlled study, it has been shown that daily ginseng intake or mg among type-2 diabetic patients demonstrated significant reduction in fasting blood glucose and body weight, and improvement in glycated hemoglobin, serum N-terminal propeptide concentration, psychological performance, and physical activities.

A continuous exposure to environmental toxins is considered to be a cause of fertility decline. Ginseng has been demonstrated to have a cytoprotective effects against these toxins, in which administration of Panax ginseng extract is reported to significantly reduce the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced pathological and genotoxical damages in rat testes. Ginsenosides are triterpenoid saponins that structurally resemble the steroid hormones.

Thus, it is tempting to speculate that the effects of ginsenosides on sexual function and spermatogenesis are a result of activation of steroid receptors. Androgens are sex steroids that are essential for the development and maintenance of male sexual characteristics, and regulate normal spermatogenesis.

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Androgen receptor AR is abundantly expressed in male genital tissues and in spermatozoa, 56 and its expression is significantly decreased in infertile men. Estrogen is another hormone with profound effects on sexual function of both male and female. Estrogen supplements have been shown to improve sexual function of testosterone deficiency men. Expression of progesterone receptor PR was observed on human sperms, and a strong correlation between PR expression and sperm function has been demonstrated. For example, the estrogen-induced forward movement of human spermatozoa into the oviduct could be effectively suppressed by progesterone.

The ginsenoside Re-induced motility enhancement effect in spermatozoa could be related to the findings that Re is found to be both ER and PR agonists. Ginseng is a vital constituent of traditional Chinese medicine and has been used to treat various physical conditions for thousands of years, importantly as an aphrodisiac and is used to treat sexual dysfunction as well as to enhance sexual behavior and gonadal functions Fig. Therefore, use of ginseng appears to be important for the development of novel therapeutics or to increase the effectiveness of the current treatment strategies for male reproductive diseases or disorders.

However, its molecular mechanisms of action remain elusive. Research in this area should be carried further. A versatile assay for high-throughput expression profiling will prove useful to reveal the molecular functions of different ginsenosides and how the different signal networks are orchestrated.

Sexual Benefits of Panax Ginseng for Men

Further evaluations are also needed to validate some of the medicinal benefits using modern analytical tools and technology-based analyses. Ginseng enhances sexual performance, improves male fertility through modulating the neuronal and hormonal systems, promotes spermatogenesis, and acts directly on sperms via steroid receptors. Ginseng also preserves male fertility during disease states.

Previously published online: National Center for Biotechnology Information , U. Journal List Spermatogenesis v. Published online Sep Author information Article notes Copyright and License information Disclaimer. Alice ST Wong, Email: Received Sep 4; Accepted Sep 5.

The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. This article has been cited by other articles in PMC. Abstract Ginseng is often referred to as the King of all herbs, and is found to be a promising agent to improve general well-being.

Introduction Infertility is a growing problem in the world. Sex Performance Erection Ginseng is commonly taken by itself or with an herbal formula to enhance sexual performance in traditional Chinese medical practices. Libido Studies on rodents reveal that both Asian ginseng Panax ginseng 16 and American ginseng Panax quinquefolium 17 can facilitate copulatory behavior. Sperm Production and Quality Researches over the past 20 y have shown sperm counts declining in many countries across the world.

Sperm count and motility The initial evidence that ginseng may have positive effects on spermatogenesis was first published in Sperm preservation Ginseng is also found to help preserve the ejaculated sperms. Effects of Ginseng on Spermatogenesis During Disease States It is known that conventional cancer treatments often lead to various degrees of reproduction impairment, and that these effects could be either temporary or permanent.

Mechanisms of Action on Spermatids Ginsenosides are triterpenoid saponins that structurally resemble the steroid hormones. Concluding Remarks and Future Perspectives Ginseng is a vital constituent of traditional Chinese medicine and has been used to treat various physical conditions for thousands of years, importantly as an aphrodisiac and is used to treat sexual dysfunction as well as to enhance sexual behavior and gonadal functions Fig.

Open in a separate window. Disclosure of Potential Conflicts of Interest No potential conflicts of interest were disclosed. Glossary Abbreviations: Notes Footnotes Previously published online: References 1. National, regional, and global trends in infertility prevalence since PLoS Med. American Society for Reproductive Medicine. Quick Facts about Infertility.

Fertil Steril. Complementary and alternative medicine utilization by a sample of infertile couples in Jordan for infertility treatment: The use of complementary medicine and therapies by patients attending a reproductive medicine unit in South Australia: Red ginseng for treating erectile dysfunction: Br J Clin Pharmacol. A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: J Urol. Study of the efficacy of Korean Red Ginseng in the treatment of erectile dysfunction.

Asian J Androl. In vitro and in vivo experimental effect of Korean red ginseng on erection. Effects of Korean ginseng berry extract GB on penile erection: Chen X, Lee TJ. Ginsenosides-induced nitric oxide-mediated relaxation of the rabbit corpus cavernosum. Br J Pharmacol.


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Ginseng, sex behavior, and nitric oxide. Ann N Y Acad Sci. Nitric oxide and penile erectile function. Pharmacol Ther. Signaling pathway of ginsenoside-Rg1 leading to nitric oxide production in endothelial cells. FEBS Lett. J Sex Med. Influence of ginseng on mating behavior of male rats. Effect of American ginseng Panax quinquefolium on male copulatory behavior in the rat. Physiol Behav. Preventive effects of various ginseng saponins on the development of copulatory disorder induced by prolonged individual housing in male mice.

Methods Find Exp Clin Pharmacol.

Should You Try Ginseng for Erectile Dysfunction Treatment - paradigmpartners.com.au

Nelson WO. The male sex hormone: Some factors controlling its production and some of its effects on the reproductive organs. Ohio J Sci. Restorative increases in serum testosterone levels are significantly correlated to improvements in sexual functioning. J Androl. Effect of Panax ginseng on testosterone level and prostate in male rats. Arch Androl. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats.

Chin J Physiol. Effects of Panax Ginseng C. Meyer saponins on male fertility. Panminerva Med. Acta Pharmacol Sin. Benishin CG. Actions of ginsenoside Rb1 on choline uptake in central cholinergic nerve endings. Neurochem Int. Men who are experiencing erectile dysfunction may want to consider adding ginseng to their treatment plan. Consult a knowledgeable healthcare provider about the most appropriate dose. Choi YD et al. Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: Kim TH et al.


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    • Effects of tissue-cultured mountain ginseng Panax ginseng CA Meyer extract on male patients with erectile dysfunction. Asian Journal of Andrology May; 11 3: Shergis JL et al. Panax ginseng in randomised controlled trials: Phytotherapy Research Jul; 27 7: Can Ginseng Treat Erectile Dysfunction? January 13, What is ginseng? Latest Articles.